| Assignment | Title/Topic Question |
| PICO 1 – Long Term Care | For elderly patients or those with a significant decline in capacity to performed activity of daily living, they are considered at risk for malnutrition. Typically, dietitians and other providers perform routine nutritional screening with oral protein or carbohydrate supplementation compared with traditional meals alone to reduce the number of pressure injuries, weight loss, and functional decline in our aging population in a long term setting |
| PICO 2- Long Term Care | In men aged 65 years and older with prostate cancer, does active oncologic treatment compared with watchful waiting or conservative management improve overall survival and preserve quality of life and functional status? |
| PICO 3- Long Term Care | In adults with distal femur fractures in subacute rehabilitation and long-term care populations, how does intramedullary nailing compared with open reduction and internal fixation using plate and screw constructs affect fracture healing outcomes, complication rates, and reoperative risk? |
| PICO 4 – Internal medicine | In adults with moderate‑to‑severe Crohn’s disease, how does anti‑TNF monoclonal antibody therapy, compared with corticosteroid‑based therapy, affect clinical remission, mucosal healing, and relapse rates? |
| PICO 5 – Internal medicine | In adults with pulmonary arterial hypertension, how does sotatercept added to standard PAH therapy, compared with standard therapy alone, affect exercise capacity, pulmonary vascular resistance, functional status, and risk of clinical worsening? |
| PICO 6 – Internal medicine | In adults with MSI-H/dMMR metastatic colorectal cancer, how does treatment with immune checkpoint inhibitors (pembrolizumab or nivolumab ± ipilimumab) compared with standard chemotherapy (FOLFOX or FOLFIRI) affect progression-free survival, overall survival, objective response rates, and treatment-related adverse events |
| Draft Mini-CAT | PICO Question: In hospitalized adult patients with sepsis, does the use of balanced crystalloids compared to normal saline improve mortality, incidence of acute kidney injury (AKI), and the need for renal replacement therapy |
| Final Mini-CAT | PICO Question: In hospitalized adult patients with sepsis, does the use of balanced crystalloids compared to normal saline improve mortality, incidence of acute kidney injury (AKI), and the need for renal replacement therapy |
